IMPORTANT NOTE

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), also known as Multiorgan hypersensitivity, has been reported in patients taking antiepileptic drugs, including Neurontin. Some of these events have been fatal or life-threatening. DRESS typically, although not exclusively, presents with fever, rash, and or lymphadenopathy, in association with other organ system involvement, such as hepatitis, nephritis, hematological abnormalities, myocarditis, or myositis sometimes resembling an acute viral infection.

Eosinophilia is often present. Because this disorder is variable in its expression, other organ systems not noted here may be involved. It is important to note that early manifestations of hypersensitivity, such as fever or lymphadenopathy, may be present even though rash is not evident. If such signs or symptoms are present, the patient should be evaluated immediately.

Neurontin should be discontinued if an alternative etiology for the signs or symptoms cannot be established. BEFORE USING THIS MEDICINE: Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking morphine, hydrocodone, or non-steriodal inflammatory medicine naproxen.

DO NOT START OR STOP

Any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including kidney problems, allergies, pregnancy, or breast-feeding. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine. HOW TO USE THIS MEDICINE: Follow the directions for taking this medicine provided by your doctor. THIS MEDICINE MAY BE SWALLOWED WHOLE, or the contents of the capsule may be dissolved in juice or sprinkled over soft foods (such as applesauce) immediately before swallowing. This medicine may be taken on an empty stomach or with food.

DO NOT TAKE ANTACIDS CONTAINING

Aluminum or magnesium within 2 hours of taking this medicine. STORE THIS MEDICINE at room temperature in a tightly-closed container, away from heat and light. Take this medicine regularly to receive the most benefit from it. Taking this medicine at the same times each day will help you to remember. CONTINUE TO TAKE THIS MEDICINE even if you feel well. Do not miss any doses.

IF YOU MISS A DOSE OF THIS MEDICINE

Take it as soon as possible. If it is less than 4 hours until your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.

CAUTIONS: DO NOT TAKE THIS MEDICINE

If you have had an allergic reaction to it or are allergic to any ingredient in this product.

DO NOT EXCEED THE RECOMMENDED DOSE

Without checking with your doctor.

DO NOT STOP TAKING THIS MEDICINE

Without first checking with your doctor. Some conditions may become worse when the medicine is suddenly stopped. Your dose may need to be slowly lowered to avoid side effects.

PRECAUTIONS

While you are taking this medicine. THIS MEDICINE WILL ADD TO THE EFFECTS OF ALCOHOL and other depressants. Ask your pharmacist if you have questions about which medicines are depressants. This medicine may cause drowsiness, dizziness, or blurred vision. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Taking this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist.

CAUTION IS ADVISED WHEN USING THIS MEDICINE IN PEDIATRIC PATIENTS

because they may be more sensitive to the effects of the drug, especially mood or behavior changes (such as mood swings, trouble with mental concentration, restlessness, hyperactivity, hostility, or aggressive behavior).

THIS MEDICINE MAY CAUSE FALSE RESULTS with some home tests that check for protein in your urine. Check with your doctor or pharmacist if you are taking this medicine and need to check for protein in your urine at home. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of taking this medicine during pregnancy. THIS MEDICINE IS EXCRETED IN BREAST MILK. IF YOU ARE OR WILL BE BREAST-FEEDING while taking this medicine, check with your doctor or pharmacist to discuss the benefits and risks to your baby.

POSSIBLE SIDE EFFECTS

SIDE EFFECTS that may occur while taking this medicine include tiredness, drowsiness, dizziness, tremor, back pain, dry mouth, constipation, increased appetite, or an upset stomach. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience decreased coordination, changes in vision (double or blurred vision), back and forth eye movements, flu-like symptoms, persistent sore throat or fever, swelling of ankles, mental or mood changes, memory loss, or trouble speaking. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

OVERDOSE

IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately. Symptoms of overdose may include double vision, slurred speech, severe sluggishness or drowsiness, or diarrhea. ADDITIONAL INFORMATION: DO NOT SHARE THIS MEDICINE with Others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF YOU WILL BE TAKING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, be sure to obtain necessary refills before your supply runs out. The information in this monograph is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This information is generalized and is not intended as specific medical advice. If you have questions about the medicines you are taking or would like more information, check with your doctor, pharmacist, or nurse.